About Lulu and Nana: Twin Girls Born Healthy After Gene Surgery As Single-Cell Embryos
Two Chinese girls, who we’ll call Lulu and Nana to protect their privacy, were born healthy a few weeks ago. Their mother Grace …
source
Website dedicated to first-time mothers
Two Chinese girls, who we’ll call Lulu and Nana to protect their privacy, were born healthy a few weeks ago. Their mother Grace …
source
Imagine the girls' reaction when they find out
Hero
We are all part of nature, people should not interfere with the flow of nature. When a person interferes with the flow of water, he changes the flow of the entire planet, we cause too much damage by changing the laws of nature, we should not go in this direction otherwise we will cease to be people
Onde esta lulu e nana hoje?
One day people will think of what was done to this man the same way we think about what happened to alan turing.
Gelecek, modern öjeni ve genetik mühendislikle şekillenecek ya da insan için bir gelecek olmayacaktır.
Doktor Jiankui He'ye bu yolun açıcısı olduğu için minnettarım. Kendisi günümüzde cezâlandırıldı ve ayıplandı ancak gelecekte saygıyla anılacak.
Thank you. ❤
воопще совесть потеряли нужно его самого к камню или к дереву пришить и то же так легко об этом расказать дураки
We've already discovered much worse things, such as nuclear reaction and rockets
But politicians don't want people to become better and conservatists kill any progress.
The progress is unstoppable! Medieval religious idiots didn't destroy the science despite all efforts, it got the revenge and will keep going
This may seem like a noble thing they are doing, but don't be fooled. IVF murders many babies and uses them as scientific research. Which I for one call it evil. Let God be God – Your Not!
He has not claimed any technological breakthroughs or changes. Assuming he is using the currently established technology for editing embryo genes, he would inevitably face the technical challenges that are currently plaguing the entire academic community.
Firstly, there is the issue of "mosaicism." Using current gene editing tools, it is highly likely that they will not only work at the single-cell stage but also potentially at later stages such as the two-cell or four-cell stages, resulting in a baby with possible genetic "mosaicism."
Normal individuals have only two genetic types, one from the father and one from the mother, while a "mosaic" baby may have three, four, or more genetic types. The effects of this on the two children are difficult to predict.
What is a mosaic: An individual with different genetic traits or mixed expressions, also refers to one of the types of chromosomal abnormalities.
Secondly, there is the "off-target" issue. Although off-target effects are not inevitable, they are also difficult to completely eliminate. The occurrence rate is related to the gene locus, cell type, gene editing tool concentration, etc. Current technological means often find it difficult to confirm all off-target mutations produced in gene editing. In other words, it may be difficult for us to fully confirm whether Lulu and Nana encountered this problem. Off-target: The current level of gene editing technology cannot guarantee a 100% success rate and specificity. There is a certain probability of "accidentally injuring" other genes while modifying the target gene, which may lead to serious consequences.
Furthermore, whether the expected effect of HIV immunity can be achieved is also a big question mark. The theoretical basis for preventing or treating AIDS by editing the CCR5 gene comes from the famous "Berlin patient" and studies of the North European CCR5 gene mutation population.
What is the Berlin patient: The first and currently the only AIDS patient in the world who has been cured. He had both AIDS and leukemia, and after receiving leukemia bone marrow transplant treatment in Berlin, Germany, his AIDS was miraculously cured. Scientists found that the bone marrow donor from Northern Europe had a congenital CCR5 gene mutation.
What is the CCR5 gene in Northern Europeans: About 10% of the Northern European population naturally lacks the CCR5 gene. Many studies have shown that this deficiency is significantly associated with their immunity to AIDS. It must be noted that the CCR5 gene deficiency produced in the laboratory is different from the CCR5 gene mutation naturally occurring in nature.
Although the experimental details and data are not yet available, based on research experience, it is considered technically difficult to ensure that the genotype they edit is exactly the same as the naturally occurring one. Furthermore, the CCR5 gene has been shown to have biological functions, and its deficiency may also increase the risk of other viral infections and even cancer.
Lastly, this mutation gene currently mainly appears in the population of Northern and Western Europeans. Introducing the same mutation into the genetic background of Chinese people may produce completely different effects.
He did it purely for his own personal reputation. He should be about to be released from prison now (to be honest, I'm not sure), but I think he should spend the rest of his life in prison. As for anyone who brings up nonsense about conspiracy theories, smears my country, and spreads rumors, I don't think I can communicate with such biased people. I have always been like this.
他并未宣称取得任何技术突破或变革。假设他正在使用目前已建立的技术来编辑受精卵的基因，他将不可避免地面临目前困扰整个学术界的技术挑战。
首先，存在“嵌合体”的问题。使用当前的基因编辑工具，很可能不仅在单细胞阶段起作用，而且在稍后的阶段，如两细胞或四细胞阶段也起作用。这可能导致出生婴儿出现基因“嵌合”现象。
通常，人类只有两种遗传类型，一种来自父亲，一种来自母亲。一个“嵌合”婴儿可能有三种、四种甚至更多种遗传类型。这对这两个孩子的影响难以预测。
其次，存在“脱靶”的问题。虽然脱靶并非必然发生，但也很难完全消除。其发生的可能性取决于基因位点、细胞类型、基因编辑工具的浓度等因素。当前的技术手段常常难以确认基因编辑过程中产生的所有离靶突变。换句话说，很难确认鹿鹿和娜娜是否遇到了这个问题。
此外，能否实现预期的艾滋病病毒免疫效果也存疑。利用基因编辑CCR5基因来预防或治疗艾滋病的理论基础来自著名的“柏林患者”以及对北欧CCR5基因突变人群的研究。
尽管没有看到实验细节和数据，但基于研究经验，人们认为很难确保他们编辑的基因型与自然存在的基因型完全一致。此外，CCR5基因已被证明具有生物学功能，其缺失也可能增加其他病毒感染甚至肿瘤的风险。
最后，这种突变基因主要出现在北欧和西欧人群中。将同样的突变引入中国人的遗传背景中可能会产生完全不同的效果。
他完全是为了自己的个人声誉才这样做的。现在他即将出狱，但我认为他应该在监狱里度过余生。至于那些提出无稽之谈阴谋论、诽谤我的国家和散布谣言的人，我觉得我无法与这些有偏见的人沟通。我一直这样。
oh thats not
Incredible 4 billion years of evolution can be reversed
OH I LOVE THIS GUY.
Watching 2024
The science is fascinating, but he was motivated by personal fame and the desire to be the "first". Which is a little scummy.
21 dec 2023
No, enhancing IQ should not be banned. Why would we want people to be stupid?
any updates ?
I agree with almost everything except 3:55. What is wrong with enhancing IQ? What if the child is shown to have a cognition problem should we correct it. Increasing IQ is the most loving thing a parent can do. Life is an iq test and those with higher intelligence make better decisions leading to more logical problems and more efficiente communities. It will also put an end to those whose identity depends on feeling superior to others.
he only has 4.13 subscribers, really? This guy did something that will change our world. Realistically it was Jenniffer Doundna and her Lab Partner. I guess my point is this video shows how dumb or the direction our world is going. This guy made a major thing, illegal but major, meanwhile Bella whatever the fuck her name is has 9.7million followers, and what has she accomplished? nothing just bobbing her head to some video. It's not going to be hard for the new world order to be established when these technologies are the thief that broke into your home while you sleep.
Катарсис?
CAN YOU END THE HERPES GENE ? WOULD LIKE TO COME TO THE UNITED STATES. ??? THIS WILL END ALZHEIMER'S.
Возможно это величайший момент в истории человечества
SEND HIM TO THE UNITED STATES, WE WILL TAKE HIM.
They punished him because genetic engineering and positive eugenics can only be accessible to the rich, everyone else will get jack.
This person is no better than Josef Mengele. SHAME ON YOU for needless experimentation on human babies and risking their lives. Shame on you for not being transparent to the scientific and ethics communities.
haram