AHS18 L. Amber O’Hearn – Inuit Ketosis and the Arctic Variant of CPT1A:
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https://nneandersphysiologicalliteracy.wordpress.com/2019/10/25/metabolic-profile-of-eskimo-low-normal-uric-acid-high-bun/
In this study the Inuit had high Urea. That should be interesting. It points to high protein intake.
You say they only had berries for 3 weeks. Please research the Inuit preservattion methods and other intakes of carbs. I love your work but please include to better your research. Much love.
Until we can confirm the safety of long-term, continuous ketosis, I choose to incorporate 4 tablespoons of honey daily into my diet, along with dairy and meat.
I just learned about the Arctic CPT1-A deficiency a few days ago and was a bit perplexed.
Then I figured; since CPT1-B and C are working as they should in Arctic people – maybe CPT1-A was regulated down to allow more fatty acids to be metabolized directly in the muscles and brain and in the cold and hostile environment that outweighs the drawbacks (infant mortality rate and so on) of the ~22% efficient CPT1-A which btw is enough to fuel neoglucogenesis for the tissues that require glucose.
I don't know, I am not an expert, just spit balling here.
Also; what about cats? I remember reading that cats aren't in ketosis but rather derive their energy solely from neoglucogenesis. Now cats aren't humans but I mean, come on! Why is it that a pure predator is not in ketosis? That question is a pretty big fish to fry.
During WW2 the American govt injected eskimos in Nome Alaska against their will with radio active isotopes in an experiment to see why they are able to with stand such cold weather.Many of them died early deaths from cancer.Sounds like some of the experiments conducted by Nazi germany on gypsies and jews during the holocaust.Makes me very angry! Especially since all they had do was ask an old eskimo and he would tell them.I've been to Nome a few times .The older eskimos would carry a flask inside their coats of coveted seal oil and put great stock in its emergency benefits claiming that if they ever get "chilled"[hypothermic]they simply swig down a shot or so of the seal oil and feel an immediate warming from the fuel.Somehow it kicks in quickly.Now I noticed when I started a high fat diet [I live in Alaska]that I could not tolerated much for coats or blankets at night for a couple of weeks.I'm not eskimo.Hope this helps.My internal furnace seemed to be burning hotter than usual.Someone needs to study the properties of seal oil.They had whale blubber but put great stock in the seal oil.
0:12 Peoples? Is this a word?
We are meant to live of the land [plant based] not animal meats . There are exceptions to the rule like Eskimos who live in sub zero temp that's not you or me . They need a high fat diet they are an exception to the rule .
Mistake in the description: "many cultures with a traditional diet of …negligible carbohydrate". There have never been many cultures with negligible carbohydrate except possibly the Inuit.
Who asked the uncoupling question?
Great talk and also good questions, absolutely fascinating topic!
It is weird that so much seems to be at stake here in terms of nutritional camps looking for historical support of a hypothesis. I like being in control of my metabolism and being able to test anything I fancy regardless of what may or may not have been true for the Inuit 2 centuries ago.
Just a small point, thought it’s not small to the Inuit, I’ll just mention that the word “Inuit” means “people.” So one doesn’t say the “Inuit people.” It’s like saying the “People people.”
A single person is called an “Inuk”. Plural is “Inuks”. I’ve had all this explained to me in the Canadian Arctic, Nunavut, by Inuktitut interpreters. Not trying to nit-pick.
Nowadays Greenlanders are incurable sweet-tooths…the few slim adults that I see around are mostly smokers (60% of adults smoke) I look out my window here in Nuuk and it seems every second Inuit Greenlander I see (30 + yo) is apple-shaped / 10-30 kg overweight.